A vital book about the next big thing in science—and yet another top-notch biography from Isaacson.

THE CODE BREAKER

JENNIFER DOUDNA, GENE EDITING, AND THE FUTURE OF THE HUMAN RACE

A magisterial biography of the co-discoverer of what has been called the greatest advance in biology since the discovery of DNA.

For the first third of Isaacson’s latest winner, the author focuses on the life and career of Jennifer Doudna (b. 1964). Raised by academic parents who encouraged her fascination with science, she flourished in college and went on to earn a doctorate in biological chemistry and molecular pharmacology from Harvard. After fellowships and postdoc programs at the University of Colorado and Yale, she joined the faculty at the University of California in 2002. In 2006, she learned about CRISPR, a system of identical repeated DNA sequences in bacteria copied from certain viruses. Others had discovered that this was a defense mechanism—CRISPR DNA generates enzymes that chop up the DNA of the infecting virus. With collaborators, she discovered how CRISPR operates and invented a much simpler technique for cutting DNA and editing genes. Although known since the 1970s, “genetic engineering” was a complex, tedious process. CRISPR made it much simpler. Formally accepted by the editors of Science in 2012, the co-authored paper galvanized the scientific establishment and led to a torrent of awards, culminating in the 2020 Nobel Prize in chemistry. At this point, Isaacson steps back, keeping Doudna as the central character but describing the rush to apply gene editing to altering life and curing diseases, the intense debate over its morality, and the often shameful quarrels over credit and patents. A diligent historian and researcher, Isaacson lucidly explains CRISPR and refuses to pass it off as a far-fetched magic show. Some scientific concepts (nuclear fission, evolution) are easy to grasp but not CRISPR. Using charts, analogies, and repeated warnings for readers to pay attention, the author describes a massively complicated operation in which humans can program heredity. Those familiar with college-level biology will have a better time, but nobody will regret the reading experience.

A vital book about the next big thing in science—and yet another top-notch biography from Isaacson.

Pub Date: March 9, 2021

ISBN: 978-1-982115-85-2

Page Count: 560

Publisher: Simon & Schuster

Review Posted Online: Jan. 6, 2021

Kirkus Reviews Issue: Feb. 1, 2021

Did you like this book?

No Comments Yet

A conversational, pleasurable look into McConaughey’s life and thought.

Reader Votes

  • Readers Vote
  • 18

Our Verdict

  • Our Verdict
  • GET IT

  • New York Times Bestseller

  • IndieBound Bestseller

GREENLIGHTS

All right, all right, all right: The affable, laconic actor delivers a combination of memoir and self-help book.

“This is an approach book,” writes McConaughey, adding that it contains “philosophies that can be objectively understood, and if you choose, subjectively adopted, by either changing your reality, or changing how you see it. This is a playbook, based on adventures in my life.” Some of those philosophies come in the form of apothegms: “When you can design your own weather, blow in the breeze”; “Simplify, focus, conserve to liberate.” Others come in the form of sometimes rambling stories that never take the shortest route from point A to point B, as when he recounts a dream-spurred, challenging visit to the Malian musician Ali Farka Touré, who offered a significant lesson in how disagreement can be expressed politely and without rancor. Fans of McConaughey will enjoy his memories—which line up squarely with other accounts in Melissa Maerz’s recent oral history, Alright, Alright, Alright—of his debut in Richard Linklater’s Dazed and Confused, to which he contributed not just that signature phrase, but also a kind of too-cool-for-school hipness that dissolves a bit upon realizing that he’s an older guy on the prowl for teenage girls. McConaughey’s prep to settle into the role of Wooderson involved inhabiting the mind of a dude who digs cars, rock ’n’ roll, and “chicks,” and he ran with it, reminding readers that the film originally had only three scripted scenes for his character. The lesson: “Do one thing well, then another. Once, then once more.” It’s clear that the author is a thoughtful man, even an intellectual of sorts, though without the earnestness of Ethan Hawke or James Franco. Though some of the sentiments are greeting card–ish, this book is entertaining and full of good lessons.

A conversational, pleasurable look into McConaughey’s life and thought.

Pub Date: Oct. 20, 2020

ISBN: 978-0-593-13913-4

Page Count: 304

Publisher: Crown

Review Posted Online: Oct. 27, 2020

Kirkus Reviews Issue: Dec. 1, 2020

Did you like this book?

A solid work of investigation that, while treading well-covered ground, offers plenty of surprises.

Reader Votes

  • Readers Vote
  • 10

Our Verdict

  • Our Verdict
  • GET IT

  • New York Times Bestseller

  • IndieBound Bestseller

PERIL

An account of the last gasps of the Trump administration, completing a trilogy begun with Fear (2018) and Rage (2020).

One of Woodward and fellow Washington Post reporter Costa’s most memorable revelations comes right away: Gen. Mark Milley, chairman of the Joint Chiefs of Staff, calling his counterpart in Beijing to assure him that even after Jan. 6 and what Milley saw as an unmistakable attempt at a coup d’état, he would keep Trump from picking a war with China. This depiction has earned much attention on the talking-heads news channels, but more significant is its follow-up: Milley did so because he was concerned that Trump “might still be looking for what Milley called a ‘Reichstag moment.’ ” Milley emerges as a stalwart protector of the Constitution who constantly courted Trump’s ire and yet somehow survived without being fired. No less concerned about Trump’s erratic behavior was Paul Ryan, the former Speaker of the House, who studied the psychiatric literature for a big takeaway: “Do not humiliate Trump in public. Humiliating a narcissist risked real danger, a frantic lashing out if he felt threatened or criticized.” Losing the 2020 election was one such humiliation, and Woodward and Costa closely track the trajectory of Trump’s reaction, from depression to howling rage to the stubborn belief that the election was rigged. There are a few other modest revelations in the book, including the fact that Trump loyalist William Barr warned him that the electorate didn’t like him. “They just think you’re a fucking asshole,” Barr told his boss. That was true enough, and the civil war that the authors recount among various offices in the White House and government reveals that Trump’s people were only ever tentatively his. All the same, the authors note, having drawn on scores of “deep background” interviews, Trump still has his base, still intends vengeance by way of a comeback, and still constitutes the peril of their title.

A solid work of investigation that, while treading well-covered ground, offers plenty of surprises.

Pub Date: Sept. 21, 2021

ISBN: 978-1-982182-91-5

Page Count: 512

Publisher: Simon & Schuster

Review Posted Online: Sept. 24, 2021

Kirkus Reviews Issue: Oct. 15, 2021

Did you like this book?

more